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Dpp4 EC/ (BMT) mice exhibited an approximately 25% decrease in plasma DPP-4 activity and an approximately 2.5-fold increase in plasma active GLP-1, without differences in body weight or levels of fasting TG, consistent with the importance of DPP-4 expression in endothelial cells (Figure 2E)

Reactive oxygen species (ROS) detection assay For C11-BODIPY staining, the C11-BODIPY reagent was added to the cell suspension to achieve a final concentration of 1 to 10 M, followed by incubation at 37 C for 30 to 60 min